Enteric-Coated PeptizymeSerrapeptase a powerful systemic enzyme
that promotes total body support. Being the most powerful Serrapeptase
on the market, Serrapeptase is unrivaled among products of its kind
because it is packed with 130K SPU per capsule (80K is also available),
the strongest in the world. Serrapeptase – also known as serrapeptidase,
serratiopeptidase and serratia peptidase – is a powerful proteolytic
enzyme derived from a species of bacteria originally found in the
intestine of silkworms. The bacterium, Serratia mercesans, produces the
enzyme serrapeptase to enable the silkworm to dissolve its silken cocoon
and emerge as a moth after metamorphosis. Serratia is now grown in
cultures to produce serrapeptase by fermentation.
The Problem with Discomfort
Systemic enzymes are essential to a
healthy lifestyle. Processed food, exposure to environmental toxins and
occasional illness cause the body to use up these enzymes, forcing it to
work even harder to make these enzymes and use them in the many complex
reactions that take place every moment in our bodies.
Many people reach for NSAIDs
(non-steroidal anti-inflammatory drugs) such as aspirin, ibuprofen and
naproxen to address discomfort. They are effective but come with
serious side effects such as gastric bleeding, joint/cartilage damage,
disrupted metabolism, increased blood sugar, loss of bone and emotional
disorders, among others. In July of 1998, The American Journal of
Medicine stated the following about NSAID-related gastrointestinal and
“Conservative calculations estimate
that approximately 107,000 patients are hospitalized annually for
non-steroidal anti-inflammatory drug (NSAID)-related gastrointestinal
(GI) complications and at least 16,500 NSAID-related deaths occur each
year among arthritis patients alone. The figures of all NSAID users
would be overwhelming, yet the scope of this problem is generally
An all-natural systemic enzyme,
serrapeptase is a catalyst that stimulates and alters the body’s own
capacity to recover with minimal side effects.
What is enteric coating, and why is it needed?
Enteric coating is a layer of protective
coating for dietary supplements that is meant to allow the supplement to
bypass digestion by the stomach and be absorbed in the small intestine.
Systemic enzymes are proteins, so their functional structures are
denatured (or destroyed) in conditions of extreme pH and temperature.
Without enteric coating, enzymes would be rendered useless long before
they reach the bloodstream, where their carry out their beneficial
What’s enteric coating made of?
At AST Enzymes, we use Methacrylic Acid
Copolymer (MAAC) for our enteric coating. Methacrylic Acid Copolymer
(MAAC) is not a phthalate. According to independent studies, MAAC is the
most gastro-resistant when compared to other commonly used enteric
coating agents such as Cellulose Acetate Phthalate (CAP) and
Hydroxypropyl Methycellulose Phthalate (HPMCP). This means that MAAC can
most effectively withstand the acidity of the stomach, allowing its
contents to be released in the small intestine and absorbed
Don’t let the name scare you. MAAC is a
food-grade compound that has been in use as enteric coating in the
pharmaceutical industry for over 50 years with no reported side effects.
In fact, the European Food Safety Authority – an organization that
conducted studies which led to the ban of 6 types of phthalates in
personal care products in Europe in 2004 – has deemed MAAC safe for use
as coating agent in food supplements.
Not only is MAAC listed as Generally
Recognized As Safe (GRAS) by the Food and Drug Administration (FDA), the
Environmental Protection Agency (EPA) also conducted various studies
and found sufficient information to reasonably conclude that the current
use pattern of MAAC will not adversely affect public health or the
Serrapeptase Units: Facts OR Fiction?!
The units of Serrapeptase seem to be quite controversial in the market of enzymes today
1. To truly understand these units let
us gather a bit of knowledge to actually understand how enzymes work.
The enzyme unit (U) is a unit for the amount of a particular enzyme. One
U is defined as the amount of the enzyme that produces a certain amount
of enzymatic activity, that is, the amount that catalyzes the
conversion of 1 micro mole of substrate per minute.
2 Enzyme activity is equal to the moles
of substrate converted per unit of time under standard conditions. An
increased amount of substrate will increase the rate of reaction with
enzymes; however, once the reaction exceeds a certain point Vmax, the
rate of reaction will become linear because the amount of active sites
will remain constant.
Figure: 1 the above figure illustrates a
Michaellis Menten Plot. This shows that an increase in substrate will
increase the reaction rate until a certain point is reached (Vmax) then
it will level off constant as all of the active sites have remained
Now that we understand how an enzyme
works on a biochemical level, how do we measure the units of activity
specifically for Serrapeptase and what do they mean? If you have been
researching the wide variety of options for Serrapeptase on the market
today you have surely come across an extensive list of units that seem
to leave people even more distraught then when they started. A shortlist
would include mg, IU, SU and SPU. Let us explore each of these units
and analyze them thoroughly in detail.
The first unit you may be familiar with
and come across is mg, also known as milligrams. This is an accurate
unit of measurement for weight; however, a weight of enzyme can contain
low activity levels or high activity levels. Ideally for the highest
quality enzyme, you would want the lowest weight and the highest
activity ensuring purity. This is why we do not look at Serrapeptase in
regards to mg weight like we would do with traditional NSAIDs,
(anti-inflammatory drugs such as Aspirin, etc). Instead, the activity
level of the enzyme is what is vital to its effectiveness in measure.
Another form of measurement, the
International Unit, (IU), has also been seen on the market to describe
the activity of Serrapeptase. The international unit is a unit of
measurement for the amount of substance; mass or volume that constitutes
one international unit caries based on the substance being measured. IU
is supposed to be used to quantify vitamins, hormones, some
medications, vaccines, and blood products. “The enzyme unit should not
be confused with the international Unit (IU), and unrelated measure of
biologically active substances.”6 Despite its name, IU is not part of
the International System of Units physics and chemistry. “The IU should
not be confused with the enzyme unit, also known as the International
unit of enzyme activity and abbreviated as U.4” Companies that continue
to use this unit (IU) to describe the activity of Serrapeptase are
Finally, you may have come across (SU)
or (SPU), both standing for Serrapeptase Unit and have been used
interchangeably by the masses. These have both been accepted and
accurate in industry; however, (SU) may draw some confusion. (SU) is a
unit used in the digestion of Invertase (Sucrase). One SU (Sumner Unit
Invertase/Sucrase) is the FCC assay of measurement, whereby one Sumner
Unit is the quantity of enzyme that will convert 1 mg of sucrose to
glucose and fructose in 5 minutes. As you can see this can become
problematic using the same units for different processes already
defined.7 While both SU and SPU are used today in industry, the most
accurate unit to describe the activity of Serrapeptase is (SPU).
As a final point in summary, the
potency of the enzyme is the most crucial factor in determining how well
it will work, and this is measured by activity not by weight. The most
accurate unit of measure for Serrapeptase is (SPU), Serrapeptase Units.
Using this one and only Unit will assure that the information is
accurate and streamline. Do not be fooled by marketing strategies of
large incorporations to fool you by lack of knowledge as a consumer.
Don’t be misled by deceiving marketing
strategies by other companies claiming to have serrapeptase with 250,000
SPU. These clever companies are misleading their customers to believe
that they have the strongest Serrapeptase by claiming that their
products contain 250,000 SPU of serrapeptase per “dosage”—which in most
cases, 2 capsules, therefore only 125,000 per capsule. Don’t let
yourself be fooled by deceptive techniques that are designed to confuse
customers. AST Enzymes is the largest manufacturer of Serrapeptase in
the world and happens to carry the strongest Serrapeptase on the market
with 130,000 SPU per capsule! Our quality and prices of our products
speak for themselves.
Our serrapeptase is enteric-coated to
survive the acidic conditions of the stomach without being degraded.
This allows for optimum absorption in the small intestine and greater
systemic activity. The pH resistant enteric coating disintegrates after
it enters the alkaline environment of the intestine.
Most serrapeptase brands on the market
are not enteric-coated, which means this low-pH sensitive enzyme can
lose activity, and thus effectiveness, when entering the stomach. The
enteric coating in Serrapeptase allows the enzymes to survive the acidic
conditions of the stomach, which increases absorption in the small
intestine, systemic activity and efficacy.